In short, one main base in hi-sec, in a central location with comparatively easy access to multiple low-sec bases, which were for fast re-shipping as needed between ship losses and a few consumables such as ammunition
The hi-sec base would be at or near a trade hub and this would be the main location for any purchased ships, common equipment such as auto-cannons and consumables such as ammunition.
Those low sec bases would change over time but they would only contain a few ships. Each of these small bases would only have one Mammoth (level IV) load of ships and equipment. This would allow that base to either be left there after moving to a new region or allow it to be easily moved, the probability being to simply leave the small stash of ships and ammunition there.

